(wow) Words Of Wonders Level 2303 Answers – This is the first episode of Nature Prodcast, a podcast produced by the Joint Genome Institute of the US Department of Energy. In each episode, we discuss the science behind natural products and metabolism, and talk to scientists working to understand nature’s amazing biochemistry!
In this introduction, Alison Takemura and Dan Udwary provide an introduction to who we are and begin to cover the basics in this area. This, along with Part 2 (here) and Part 3 (here) is a good place to start if you don’t know much about natural products.
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DAN: You’re listening to the podcast “Natural Prodcast” of the Joint Genome Institute of the US Department of Energy about the science and scientists of secondary metabolism.
Dan: Hello and welcome to the first episode of the Natura Prodcast. First, maybe a little background. My name is Dan Udwary. I—along with co-host Alison Takemura, whose voice you’ll hear in a few minutes—of the Joint Genome Institute of the US Department of Energy, OR. is a DOE science office located at Lawrence Berkeley National Laboratory. Being a user tool means that scientists around the world are bringing us big energy and environmental problems – problems that require specialized DNA sequencing, genomics, metabolomics, and synthetic biology technologies that may not be available in their labs. And we use our resources to help them solve these problems. It’s a great place to work and it’s the best place I’ve ever worked.
So, okay, that’s good and all, but what are the wonders of nature? Well, of course pun – podcast about natural products. And natural products is an old term for special natural chemical compounds found in plants, fungi and bacteria, almost all living things. When your crazy aunt posts on Facebook that cinnamon or turmeric cures ailments and helps you sleep (I’m not sure if that’s a real example), she’s talking about natural products, even if that Facebook science might be. More than a little unclear. But the field of natural products – or secondary metabolism – is real, and it’s a field with very real and amazing science, with a long history, and that’s what we’re going to talk about here.
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, as an institution that recognizes the importance of natural products in understanding the natural environment, our director, Nigel Mouncey, started and ran the secondary metabolic science program that I enrolled in, and my job was to do good research. , and to talk to the broader natural products community about what they need to advance their science and what they can do about it.
So here we are. This is the first episode and I will be releasing 5 more so you can Get the feeling that this podcast is all about. The first three parts are called the introduction. We want to try to convey to the general public some basics of natural product science, and of course the word Primer is a molecular biology term. We recorded the Primer as a longer conversation that I cut into several subsections. If you are an expert in the field, you may skip straight to Episodes 4, 5 and 6 for a fun interview, unless you want to check us out. I love fact checking, so go crazy.
But here, in this first episode, you meet me and my co-host, Alison. We will tell you some stories about natural products so that you understand why I think they are so important, and we will begin to explain some terms and basics that you, the audience, are not familiar with. , so you can get a sense of what it’s all about. In the second part, we discuss the difference between primary and secondary metabolism and the early history of the field. Then, in the third episode, the modern history of natural products and where we are today.
Then we had some great conversations that we’ve already recorded with some great scientists and may continue to do so for some time. To be fair, it might help to have a basic knowledge of modern biology. We try to make it as general as possible, but scientists like words. If you don’t have that foundation, everyone starts somewhere, right? Most of what you need to know is a quick Google search!
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If you like these first episodes, let me know at [email protected] or on Twitter @ or @danudwary. We’ll probably do a few more between interviews as we go, so if you hear a topic you’d like us to get into, let us know!
Dan: So we’re doing this podcast about secondary metabolism. And I think it’s a good idea to have an opportunity to talk more about some of the basics and some of the reasons why we want to do this. And also provides a little more information and context for those who might be interested in listening to the second metabolism podcast. Maybe not many people want to do this, but I still think so
DAN: Yes, maybe, and I think one of the fun things I hope to bring up today is why secondary metabolism is interesting and why we need more people working in this area and why we need people who are not licensed. Work in this area. Well, I think we will go through the basics of science and the history of the field a little bit, and go through the current situation so that when you talk to other scientists, you have a better idea. What happened and what is the context of their work.
ALISON: Yes. This sounds good. I am very glad that you invited me to this discussion today. And I wonder who we start with.
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ALISON: Of course. So my name is Alison Takemura, and I work here with you, Dan, at the Genome Institute together. And would you like to hear a little about my background?
ALISON: Yes. Okay, so I got my PhD in microbiology at MIT and studied microbial ecology. I studied the species of Vibrio in the ocean, ie. Heterotrophic bacteria. Well, in my study, we don’t really deal with secondary metabolites. So it’s an area that is adjacent to what I’m working on, but my experience with the interaction of the environment of microbes, for example, my journey to explore the world, I feel the great importance of molecules that are shared and expressed. . And it seems that we still don’t know much about this world. So I’m very interested to hear more about it. And I am happy to talk with you, experts. Dan is an expert…
ALISON: People who work in this field. And again, I’m glad to talk with you, Dan, because you work in this area.
DAN: Well, it’s good to have someone who can be and follow me. And it’s always nice talking to you. So I think it will be a fun conversation.
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So I am Dan Udwary. I am a researcher in the Secondary Metabolite Science Program that the Nova Group has established under the guidance of a director with a long history in secondary metabolism. I have been involved in secondary metabolism for almost 20 years. Which, when I calculated, surprised me. I started working on secondary metabolism in graduate school. I entered the laboratory of Professor Craig Townsend at Johns Hopkins University. He does the biosynthesis of natural product molecules and explores the intersection of biochemistry and synthetic chemistry. I did postdoctoral work with Brad Moore, who we will be talking to in a few weeks at the Scripps Institution of Oceanography. He got me into the genomics of microbes, especially ocean microbes, and he’s produced some great natural products that we’ll discuss with him.
DAN: Yes, absolutely. And then I was a teacher
